• Introduction to Gastrointestinal Tumors
    • Gastric Cancer

      China is one of the countries with highest incidence of gastric cancer and new cases of gastric cancer account with accounts for more than 40% of the world’s total. According to the latest statistics, there were about 679,000 new cases of gastric cancer in 2015 with death toll of about 498,000, making the mortality rate second highest. Irregular diets, Helicobacter pylori infection and genetic factors are major causes of gastric cancer. Targeted treatments that are more specific in gastric cancer include corresponding treatments for Her2-positive patients. There are also some new targeted therapies (e.g. for MET) that are still under development.

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    • Intestinal Cancer

      Intestinal cancer is a type of malignant tumor commonly found among digestive tract. Incidence in China is currently low as compared to other parts of the world. Recent statistics reported about 390,000 new cases of intestinal cancer in 2015, ranking it third. Dietary habits, smoking, drinking, and genetic factors are key causes of bowel cancer.

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    • Gastrointestinal Stromal Tumors

      Gastrointestinal stromal tumors account for 1-3% of gastrointestinal malignancies. The estimated annual incidence rate is about 10-20 per million. It is found to be more common in middle-aged and elderly patients. Patients under 40 years old are rare, and there is no significant difference in the incidence rate between men and women. Most  GIST occurs in the stomach (50-70%) and the small intestine (20-30%), while development in the colorectal accounts for about 10-20%, and the esophagus accounts for 0-6%. It is rare in the mesentery, omentum and retroperitoneum.

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    • Liver Cancer

      Liver cancer is one of the malignant tumors that seriously threaten human health. It is known for its high invasiveness and high mortality. Over 50% of the total number of deaths from liver cancer worldwide comes from China. At present, it is believed that the occurrence and development of HCC (hepatic cell carcinoma) is mostly caused by the interaction of genetic and environmental factors, multiple incentives, multi-gene participation and multi-step regulation. Key causes of liver cancer include viral hepatitis, non-alcoholic fatty liver disease and alcoholic liver disease.

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    • Cholangiocarcinoma

      Cholangiocarcinoma is a malignant tumor originating from the epithelial cells of the bile duct. It is rare in clinical practice but yet there are many patients with cholangiocarcinoma in China. Cholangiocarcinoma is associated with bile duct stones, biliary bacterial infections and parasitic infections, primary sclerosing cholangitis, biliary cysts (including Caroli disease and choledochal cysts), viral hepatitis B and C and genetic factors.

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    • Pancreatic Cancer

      The malignant degree of pancreatic cancer is extremely high. In recent years, the incidence rate has shown an obvious upward trend. In 2015, the number of newly diagnosed cases was about 70,000. The causes of pancreatic cancer have not been fully determined. Epidemiological investigations showed that the incidence of pancreatic cancer is related to smoking, drinking, high-fat and high-protein diet, excessive drinking of coffee, environmental pollution and genetic factors.

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  • Significance of Gene testing in Gastrointestinal Tumors
    • Significance of Gene testing in Gastrointestinal Tumors

      Screening can help to accurately match the targeted/immune drugs, predict the sensitivity and side effects of chemotherapy drugs, and indicate the risk of hereditary cancer in patients with digestive tract tumors.

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  • Genetron’s Genomic Testing for Gastrointestinal Tumors
    • Onco PanScan™️ (tissue/blood)

      Product Overview:

      Combined with Genetron’s universal tumor database, the solid tumor 825 genes testing covers an updated version of the WHO, NCCN, ESMO and other authoritative guidelines and expert consensus recommended test genes. Based on the high-throughput, highly sensitive NGS platform and 'hybrid capture' technology, solid tumor 825 genes testing can provide multi-dimensional immunotherapy related biomarker detection (TMB, MSI, PD-L1, immune efficacy related gene variation), so as to guide the individualized diagnosis and treatment of tumor patients more accurately, It also provides more comprehensive reference information for researchers

      Product Features:

      1. Focus on 238 tumor drugs, covering 12 classic tumor signaling pathways, 45 chemotherapy drug related sites, 90 immunotherapy related genes, 149 tumor genetic susceptibility genes

      2. Comprehensive and real-time dynamic monitoring of recurrent metastasis and the mechanism of molecular change in drug-resistant patients, to achieve the full course of cancer monitoring and management

      3. Multi-dimensional immunotherapy assessment

      Suitable Patient Profile:

      Tumor patients seeking more opportunities for targeted drugs or immunotherapy

    • Gastrointestinal 12 genes testing (tissue/blood)

      Product Overview:

      Using advanced targeted capture technology and NGS sequencing platform while relying on NCCN guidelines for colorectal cancer and gastric cancer, important high frequency variant genes and common drug resistance genes are selected as well as chemotherapeutic drug efficacy related sites. All accounting for a total of 12 genes

      Product Features:

      Recommended by guidelines, cost-effective, widely applicable

      Suitable Patient Profile:

      Patients with gastric cancer who need to be monitored for efficacy, drug resistance and recurrence

    • MSI Microsatellite Instability Test

      Product Overview:

      Based on internationally recognized gold standard MSI screening test, and using multiplex PCR-capillary electrophoresis,  MSI status in tissue samples can now be identified accurately and comprehensively

      Product Features:

      Gold standard, accurate and comprehensive, intuitive results

      Suitable Patient Profile:

      Patients with stage II colorectal cancer, patients with advanced colorectal cancer who require immunotherapy, and people at risk of Lynch syndrome

    • Whole Exome Sequencing

      Product Overview:

      The most complete detection products at present

      Product Features:

      Contains more than 21,000 human genes

      Suitable Patient Profile:

      Patients who want to fully understand the disease situation and  patients seeking medical treatment abroad

  • Assessment Process
    • Assessment Process
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